In this review, data from all sources are tabulated to provide a handy clinical reference.Īcyclovir, valacyclovir hydrochloride, and famciclovir are the 3 antiviral drugs routinely used to treat symptomatic herpes simplex virus (HSV) infections. Then, an evidence-based dosing regimen must be selected. The physician must first choose an approach to treatment (ie, intermittent episodic therapy, intermittent suppressive therapy, or chronic suppressive therapy) based on defined clinical characteristics and patient preference. Whereas the diagnosis of this condition is often straightforward, choosing an appropriate drug (eg, acyclovir, valacyclovir hydrochloride, or famciclovir) and dosing regimen can be confusing in view of (1) competing clinical approaches to therapy (2) evolving dosing schedules based on new research (3) approved regimens of the Food and Drug Administration that may not match recommendations of the Centers for Disease Control and Prevention or of other experts and (4) dissimilar regimens for oral and genital infections. Genital and labial herpes simplex virus infections are frequently encountered by primary care physicians in the United States.
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